On a smaller budget, you could stay at Super 8 By Wyndham Carbondale, where prices are about 67US$ per night on average.
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For those who have come for business purposes, Econo Lodge Inn & Suites is a good place, a 25-minute walk from Amplitheatre. For a relaxing vacation, reserve a resort hotel near The Science Center Of Southern Illinois, such as Quality Inn Carbondale University Area or Holiday Inn Carbondale Conference Center.