21C Museum Hotel  4 stars

700 W. Main Street, Louisville, United States, 40202  show mapSave
  • Overview
  • Rooms & Availability
  • Location
  • Guest reviews
  • Facilities

Editorial review:

The novelty alone of staying in a 24-hour museum is sufficient to sell you on the idea. And then there is the fact that it is visually stunning, from the lobby which features rotating exhibits of engaging works by living artists, to the numerous pieces which adorn the halls, elevators as well as the out of this world Proof on Main restaurant. The rooms are in cool tones and sport exposed brick and all the latest gadgets, such as 42-inch HDTVs, WiFi, 500 thread count sheets) and delightfully quirky touches such as rubber duckies in the bath and silver cups.

Verified Reviews:

  • No hot water in the evening - Quiet air conditioning - Bar is fantastic
  • No pool - Free wi-fi internet - Bed was very comfortable
  • Bathroom were very nice - Food was great - Pet friendly
  • Friendly staff - Room was extremely clean - Service at breakfast was really slow
  • Wonderfully located downtown - Lobby gallery is also gorgeous - Valet parking was 15/day


The 21c Museum Hotel is situated in the heart of Museum Row in historic downtown Louisville, close to Louisville Slugger Museum and Louisville Science Center.

The four-star boutique venue with traditional Southern design features contemporary art museum, seven meeting rooms, in-house spa and fitness center.

Guests are offered 90 rooms spread over series of 19th century tobacco and bourbon warehouses, equipped with high ceilings, large windows, plush bedding, custom furniture, plush bathrobes and fully stocked mini-bar.

The property offers to have breakfast, lunch and dinner at the restaurant or in your room.

Year renovated   2006.  Number of rooms   200.

Distance to:


All rooms and suites are fitted with up-to-date amenities, including iPod docking station, poster art, 42inch HDTV flat screen television with cable channels, luxurious bedding, complimentary high-speed internet access, coffee maker, large work desks with ergonomic chair, access to the in-house spa and well-stocked mini-bar.

Dining options

The hotel restaurant serves wide range of local and international dishes, homemade pastry and bakery, and selection of refreshing drinks in attractive atmosphere.

A full breakfast is served at affordable prices. 


The meeting facilities include one large atrium for up to 120 persons, four private meeting areas from 10 to 60 persons, boardroom with audio-visual capabilities, 42inch flat screen and conference phone for up to 12 persons, and business center with state-of-the-art audio-visual equipment and wireless high-speed internet access.


The in-house spa features massage rooms, sauna, steam room and fitness facility, offering wide range of therapies, massages and treatments, as well as modern training equipment.

Additional features

The additional facilities comprise 24-hour reception, room service, airport transportation service, safe deposit box at front desk, elevator, laundry, dry cleaning, babysitting, non-smoking facilities and tour desk.

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General information



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  • Parking
  • Safe deposit box
  • Pets allowed
  • Elevator
  • ATM/Cash machine
  • Multilingual staff
  • Concierge desk
  • Storage space
  • 24-Hour Front Desk
  • Tour desk

Wireless internet is available in public areas and is free of charge

Guest Parking

Private hotel parking is possible on site and the rate is USD 26 per day.

  • Limousine service
  • Valet parking
  • Laundry
Dining facilities
  • Bar/Lounge
  • Restaurant
Business facilities
  • Wi-Fi Internet
Facilities for people with disabilities
  • Rooms/facilities for people with disabilities
Leisure and relaxation facilities
  • Sauna
  • Bicycle rentals
Room facilities
  • Non-smoking rooms
  • Air conditioning
  • Room service
  • Heating
  • Cable TV
  • Ironing facilities
  • LCD TV
  • Ergonomic chair
  • Bottled water
  • Work desk
  • Hair dryer
  • AM/FM alarm clock
  • Telephone
  • Mini bar
  • Radio
  • Toilet
  • Balcony
  • Turndown service
  • Bathrobe
  • Terrace
  • Dressing area
  • iPod docking station



from  4 pm


until  11 am

Children and extra beds
  • Older children/adults may stay at the price of USD 30 per person per night in an extra bed. 

Pets are allowed on request

Travelers’ questions & answers

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All rooms and suites are fitted with up-to-date amenities, including iPod docking station, poster art, 42inch HDTV flat screen television with cable channels, luxurious bedding, complimentary high-speed internet access, coffee maker, large work desks with ergonomic chair, access to the in-house spa and well-stocked mini-bar.

Guest Room
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Room facilities
    Luxury Double Room
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    Bed type: King Size Bed
    Room facilities
      Luxury Rooftop Double Room
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      Bed type: King Size Bed
      Room facilities

        21C Museum Hotel LocationWhat's nearby

        • Current hotel
        • Hotels nearby
        • Airports
        • Underground stations
        • Train stations
        • Parks
        • Tourist attractions
        • Museums
        • Convention centers
        • Stadiums
        • Food and meals
        • General

        Hover above the icons to see hotel photo and details.

        Click the hotel to go to the main hotel page.

        What's nearby

        What's nearby.

        Louisville Science Center, Louisville Slugger Museum, Kentucky Art and Craft Gallery are 100m away.

        Actors Theatre of Louisville, Kentucky International Convention Center and Louisville Gardens are 500m away.

        Muhammad Ali Center, Western KY Federal Community, W L Brown Lyons Theatre and Louisville/Jeffersonville Amtrak are 1.2km away.

        Tourist attractions
        • Actors Theatre of Louisville
          1700 ft
        • Downtown
          2000 ft
        • Louisville/Jeffersonville Amtrak
          4000 ft
        Popular areas
        • Belle of Louisville & Spirit of Jefferson
          2700 ft
        Places of interest
        Convention centers
        • It's Your Quarter Inc
          2300 ft
        Monuments and Landmarks
        Historical sites
        • Glassworks
          700 ft
        • Louisville Gardens
          2000 ft
        • Louisville Science Ctr
          400 ft
        • Arts Kentucky
          400 ft
        • 400 ft
        • Kentucky Art and Craft Gallery
          400 ft
        • Muhammad Ali Cente
          700 ft
        • Brennan House Inc
          3300 ft
        • Galerie Hertz
          4000 ft
        Universities, Institutes
        • Kentucky Tech Jefferson Campus
          2700 ft
        • Health Institute of Louisville
          3300 ft
        Medical care and Hospitals

        Local Attractions

        • Thomas Edison Butchertown House
          1.2 mi
          729 East Washington Street, Louisville
        • Falls of the Ohio State Park
          1.3 mi
          201 West Riverside Dr., Clarksville
        • Atlantis Waterpark
          1.7 mi
          515 Marriott Drive, Clarksville
        • Derby Dinner Playhouse
          1.9 mi
          525 Marrott Dr, Clarksville
        • Conrad-Caldwell House Museum (Conrad's Castle)
          1.9 mi
          1402 St. James Court, Louisville

        Near the hotel

        • Louisville Slugger Museum & Factory
          600 ft
          800 West Main St., Louisville
        • Louisville Science Center
          100 ft
          727 W. Main Street, Louisville
        • Kentucky Museum of Art and Craft
          100 ft
          715 West Main St., Louisville
        • Muhammad Ali Center
          600 ft
          144 N. Sixth Street, Louisville
        • Frazier History Museum
          900 ft
          829 West Main Street, Louisville
        • KentuckyShow!
          900 ft
          501 West Main Street, Louisville
        • The Kentucky Center and Brown Theatre
          900 ft
          501 West Main Street, Louisville

        Restaurants Nearby

        • Luigi's Pizzeria

          69% likes this, based on 40 reviews
          Cuisine: Pizza

          100 ft
          712 W Main St

          Phone: (502) 589-0005

        • The St. Charles Exchange

          63% likes this, based on 70 reviews
          Cuisine: American
          Price Range: USD 31 - USD 50

          200 ft
          113 South 7th Street

          Phone: 502.618.1917

        • Mrs. Potter's Coffee Lounge & Cafe

          65% likes this, based on 49 reviews
          Cuisine: Coffee Shop

          300 ft
          718 W. Main St., Suite 1N

          Phone: 502-581-1867

        • Main Eatery

          64% likes this, based on 47 reviews

          300 ft
          643 W Main St

          Phone: 502-589-7200

        • Morton's - The Steakhouse

          69% likes this, based on 91 reviews
          Cuisine: Steakhouse
          Price Range: USD 60 - USD 80

          400 ft
          626 West Main Street

          Phone: (502) 584-0421

        Getting there.

        Louisville International Airport is approximately 20 minutes from the venue.

        From the airport follow signs for I-264 (Watterson Expressway) East and downtown, take the I-264 east to I-65 North, take exit 136C, follow on W. Jefferson Street to 7th Street, take right and the hotel entrance with valet parking will be three blocks up, just before Main Street.

        Getting around.

        Louisville International Airport is 10km away.

        Louisville railway station is 2.5km away.

        21C Museum Hotel Reviews

        Guest reviews are submitted by our customers after their stay at 21C Museum Hotel

        Average guest rating

        out of 10
        Based on 38 reviews

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        Individual guest reviews

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